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Ipamorelin Reviews An evidence-appraisal digest of the ipamorelin literature — from the founding selectivity data to anti-doping detection science.

SOURCES

Ipamorelin references for each study discussed here

Open the medical papers and see whether each finding came from people, animals, or a lab test.

Return to the studiesAbout the review

What each source tested and who was studied

Danish researchers sought a drug that would wake the growth gland while leaving stress hormones alone. Later work with patients didn't show a lasting health benefit.

I gathered the papers so you can check each claim. They cover animals, blood timing, the failed Phase 2 bowel trial, CJC-1295 tests, and sports urine screens.

Each note tells you whether the work involved people, animals, or lab samples. The links let you open the paper and see who was tested, what doctors measured, and whether the result applies to your question.

  1. Raun K, Hansen BS, Johansen NL, Thogersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561. ↗
  2. Gobburu JV, Agerso H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999;16(9):1412-1416. ↗
  3. Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014;29(12):1527-1534. ↗
  4. Johansen PB, Nowak J, Skjaerbaek C, Flyvbjerg A, Andreassen TT, Wilken M, Orskov H. Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats. Growth Horm IGF Res. 1999;9(2):106-113. ↗
  5. Lu Z, Ngan MP, Liu JYH, Yang L, Tu L, Chan SW, Giuliano C, Lovati E, Pietra C, Rudd JA. The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism. Physiol Behav. 2024;284:114644. ↗
  6. Stokes AH, Falls JG, Yoon L, Cariello N, Faiola B, Colton HM, Jordan HL, Berridge BR. Integrated approach to early detection of cardiovascular toxicity induced by a ghrelin receptor agonist. Int J Toxicol. 2015;34(2):151-161. ↗
  7. Gajda PM, et al. Glycine-modified growth hormone secretagogues identified in seized doping material. Drug Test Anal. 2019;11:350-354. ↗
  8. Tsivou M, et al. Doping control container for urine stabilization: a pilot study. Drug Test Anal. 2017;9:699-712. ↗
  9. Thomas A, et al. Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry. J Sep Sci. 2016;39:333-341. ↗
  10. Semenistaya E, et al. Solid-phase extraction of small biologically active peptides on cartridges and microelution 96-well plates from human urine. Drug Test Anal. 2016;8:940-949. ↗
  11. Thomas A, et al. Metabolism of growth hormone releasing peptides. Anal Chem. 2012;84:10252-10259. ↗
  12. Yagi H, et al. Effect of intravenous or intracerebroventricular injections of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on GH release in conscious, freely moving male rats. Neuroendocrinology. 1996;63:198-206. ↗
  13. Bercu BB, et al. Role of selected endogenous peptides in growth hormone-releasing hexapeptide activity: analysis of growth hormone-releasing hormone, thyroid hormone-releasing hormone, and gonadotropin-releasing hormone. Endocrinology. 1992;130:2579-2586. ↗
  14. Fintini D, et al. Effects of combined long-term treatment with a growth hormone-releasing hormone analogue and a growth hormone secretagogue in the growth hormone-releasing hormone knock out mouse. Neuroendocrinology. 2005;82:198-207. ↗
  15. Yan M, et al. Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of GH, pituitary transcription factor-1, GHRH-receptor, GH-secretagogue-receptor and somatostatin receptor mRNAs in ovine pituitary cells. Eur J Endocrinol. 2004;150:235-242. ↗